Since 2009, the Tox21 project has screened∼ 8500 chemicals in more than 70 high-
throughput assays, generating upward of 100 million data points, with all data publicly …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Target-specific, mechanism-oriented in vitro assays post a promising alternative to
traditional animal toxicology studies. Here we report the first comprehensive analysis of the …

Tens of thousands of chemicals with poorly understood biological properties are released
into the environment each day. High-throughput screening (HTS) is potentially a more …

Toxicity analysis is a major challenge in drug design and discovery. Recently significant
progress has been made through machine learning due to its accuracy, efficiency, and lower …

Xenoestrogens and phytoestrogens are referred to as “foreign estrogens” that are produced
outside of the human body and have been shown to exert estrogen-like activity …

Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and
Brisdelle, was first marketed in the US in 1992. Effective for major depression and various …

In the 21st century and especially during a pandemic, the diagnosis and treatment of
depression is an essential part of the daily practice of many family doctors. It mainly affects …

Current antimicrobial susceptibility testing has limited screening capability for identifying
empirical antibiotic combinations to treat severe bacterial infections with multidrug-resistant …

Background: A central challenge in toxicity testing is the large number of chemicals in
commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing …