Animal models for neonatal brain injury induced by hypoxic ischemic conditions in rodents

N Hamdy, S Eide, HS Sun, ZP Feng - Experimental Neurology, 2020 - Elsevier
Neonatal hypoxia-ischemia and resulting encephalopathies are of significant concern.
Intrapartum asphyxia is a leading cause of neonatal death globally. Among surviving infants …

Current therapies for neonatal hypoxic–ischaemic and infection-sensitised hypoxic–ischaemic brain damage

K Tetorou, C Sisa, A Iqbal, K Dhillon… - Frontiers in synaptic …, 2021 - frontiersin.org
Neonatal hypoxic–ischaemic brain damage is a leading cause of child mortality and
morbidity, including cerebral palsy, epilepsy, and cognitive disabilities. The majority of …

Glutamate transport and preterm brain injury

S Pregnolato, E Chakkarapani, AR Isles… - Frontiers in …, 2019 - frontiersin.org
Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents

CA Ruff, SD Faulkner, P Rumajogee, S Beldick… - PloS one, 2017 - journals.plos.org
Background Cerebral Palsy (CP) is the most common physical pediatric
neurodevelopmental disorder and spastic diplegic injury is its most frequent subtype. CP …

Structural brain changes during the neonatal period in a rabbit model of intrauterine growth restriction

L Pla, M Illa, C Loreiro, MC Lopez… - Developmental …, 2021 - karger.com
Background: Intrauterine growth restriction (IUGR) is associated with abnormal
neurodevelopment, but the associated structural brain changes are poorly documented. The …

Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions

R Tachibana, T Umekawa, K Yoshikawa, T Owa… - Scientific reports, 2019 - nature.com
We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine
methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR) …

Locomotion is impacted differently according to the perinatal brain injury model: Meta-analysis of preclinical studies with implications for cerebral palsy

S da Conceição Pereira, R Manhães-de-Castro… - Journal of Neuroscience …, 2021 - Elsevier
Background Different approaches to reproduce cerebral palsy (CP) in animals, contribute to
the knowledge of the pathophysiological mechanism of this disease and provide a basis for …

Transition to extrauterine life and the modeling of perinatal asphyxia in rats

M Ortiz, F Loidl… - WIREs Mechanisms of …, 2022 - Wiley Online Library
Generation of murine models for the study of birth‐related pathologies has proven to be a
complex and controversial problem. Differences in the relative timing of developmental …

Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage

SY Ahn, H Jie, WB Jung, JH Jeong, S Ko, GH Im… - Experimental …, 2021 - Elsevier
Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic
deficits such as cognitive disabilities. Recently, the intraventricular transplantation of …

Maternal recurrent pregnancy loss is associated with an increased risk for long‐term neurological morbidity in offspring

D Paz Levy, T Wainstock, E Sheiner… - … Medicine & Child …, 2019 - Wiley Online Library
Aim To determine whether maternal history of recurrent pregnancy loss (RPL) impacts on
the long‐term neurological health of the offspring. Method A population‐based cohort …