Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …
[HTML][HTML] Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
[HTML][HTML] Virological features and pathogenicity of SARS-CoV-2 Omicron BA. 2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 was a
dominant circulating SARS-CoV-2 variant worldwide. Recent reports hint that BA. 2 is …
dominant circulating SARS-CoV-2 variant worldwide. Recent reports hint that BA. 2 is …
[HTML][HTML] Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity
Y Mitsui, T Suzuki, K Kuniyoshi, J Inamo, K Yamaguchi… - Immunity, 2023 - cell.com
Lung infection during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via
the angiotensin-I-converting enzyme 2 (ACE2) receptor induces a cytokine storm. However …
the angiotensin-I-converting enzyme 2 (ACE2) receptor induces a cytokine storm. However …
Cardiac side effects of RNA‐based SARS‐CoV‐2 vaccines: hidden cardiotoxic effects of mRNA‐1273 and BNT162b2 on ventricular myocyte function and structure
R Schreckenberg, N Woitasky, N Itani… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose To protect against SARS‐CoV‐2 infection, the first mRNA‐
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …
based vaccines, Spikevax (mRNA‐1273, Moderna) and Comirnaty (BNT162b2 …
[HTML][HTML] Impaired immune response drives age-dependent severity of COVID-19
J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York city
ABSTRACT Millions of Norway rats (Rattus norvegicus) inhabit New York City (NYC),
presenting the potential for transmission of severe acute respiratory syndrome coronavirus 2 …
presenting the potential for transmission of severe acute respiratory syndrome coronavirus 2 …
[HTML][HTML] Rational design of a booster vaccine against COVID-19 based on antigenic distance
Current COVID-19 vaccines are highly effective against symptomatic disease, but repeated
booster doses using vaccines based on the ancestral strain offer limited additional …
booster doses using vaccines based on the ancestral strain offer limited additional …
ACE2 and TMPRSS2 distribution in the respiratory tract of different animal species and its correlation with SARS-CoV-2 tissue tropism
M Carossino, S Izadmehr, JD Trujillo… - Microbiology …, 2024 - Am Soc Microbiol
ABSTRACT A wide range of animal species show variable susceptibility to SARS-CoV-2;
however, host factors associated with varied susceptibility remain to be defined. Here, we …
however, host factors associated with varied susceptibility remain to be defined. Here, we …
A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection
R Abdelnabi, CS Foo, SJF Kaptein… - Journal of …, 2022 - Am Soc Microbiol
Ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lacks the intrinsic
ability to bind to the mouse ACE2 receptor, and therefore establishment of SARS-CoV-2 …
ability to bind to the mouse ACE2 receptor, and therefore establishment of SARS-CoV-2 …