The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy
metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives …

Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

The importance of pyrimidines lies in the fact that they are structural components of a broad
spectrum of key molecules that participate in diverse cellular functions, such as synthesis of …

The metabolic responses of cows undergo substantial changes during the transition from
late pregnancy to early lactation. However, the molecular mechanisms associated with these …

Highlights•Human pyrimidine nucleotide biosynthesis has been targeted for the treatment of
many diseases.•Chemotherapy combining DHODH and UCK inhibitors can be a broad …

From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Duchenne muscular dystrophy is caused by the loss of functional dystrophin that secondarily
causes systemic metabolic impairment in skeletal muscles and cardiomyocytes. The …

Activation of orexigenic AgRP-expressing neurons in the arcuate nucleus of the
hypothalamus potently promotes feeding, thus defining new regulators of AgRP neuron …

Long-term hyperglycemia in diabetes mellitus is associated with complex damage to
cardiomyocytes and the development of mitochondrial dysfunction in the myocardium …