Cardiovascular risks and benefits of moderate and heavy alcohol consumption

J Fernandez-Sola - Nature Reviews Cardiology, 2015 - nature.com
The heart and vascular system are susceptible to the harmful effects of alcohol. Alcohol is an
active toxin that undergoes widespread diffusion throughout the body, causing multiple …

Ethanol metabolism and effects: nitric oxide and its interaction

XS Deng, RA Deitrich - Current clinical pharmacology, 2007 - ingentaconnect.com
Ethanol (EtOH) in alcoholic beverages is consumed by a large number of individuals and its
elimination is primarily by oxidation. The role of nitric oxide (NO) in EtOH's effects is …

Vascular actions of nitric oxide as affected by exposure to alcohol

N Toda, K Ayajiki - Alcohol & Alcoholism, 2010 - academic.oup.com
Vasodilator substances liberated from endothelial cells, mainly nitric oxide (NO), play
important roles in physiologically regulating blood flow and blood pressure and preventing …

Dose response of alcohol-induced changes in BP, nitric oxide and antioxidants in rat plasma

K Husain, J Mejia, J Lalla, S Kazim - Pharmacological research, 2005 - Elsevier
Moderate ethanol consumption is known to reduce the risk of cardiovascular diseases;
however, chronic high dose ethanol ingestion causes cardiovascular injuries including …

Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects

MM El-Mas, AA Abdel-Rahman - … to Human Health and Precision Medicine, 2019 - Springer
Several review articles have been published on the neurobehavioral actions of
acetaldehyde and other ethanol metabolites as well as in major alcohol-related disorders …

Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin …

NA Al-Awwadi, A Bornet, J Azay, C Araiz… - Journal of Agricultural …, 2004 - ACS Publications
The effects of a red wine polyphenolic extract (RWPE), ethanol, or both combined were
evaluated in insulin resistant rats. Rats were fed for 6 weeks with fructose (60%)-enriched …

Cerebral hemorrhage and alcohol exposure: a review

J Peng, H Wang, X Rong, L He, L Xiangpen… - Alcohol and …, 2020 - academic.oup.com
Aims To investigate the dose–response relationships between alcohol and intracerebral
hemorrhage (ICH), the impact of alcohol on the outcome of ICH and possible mechanisms …

Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats

MM El-Mas, J Zhang… - Journal of Applied …, 2006 - journals.physiology.org
Previous reports from our laboratory have shown that ethanol elicits hypotension in female
but not in male rats and that this effect of ethanol is estrogen dependent (El-Mass MM and …

Pathophysiological consequences of at-risk alcohol use; Implications for comorbidity risk in persons living with human immunodeficiency virus

L Simon, S Edwards, PE Molina - Frontiers in physiology, 2022 - frontiersin.org
At-risk alcohol use is a significant risk factor associated with multisystemic
pathophysiological effects leading to multiorgan injury and contributing to 5.3% of all deaths …

Chronic ethanol increases fetal cerebral blood flow specific to the ethanol‐sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine …

SE Parnell, J Ramadoss, MD Delp… - Experimental …, 2007 - Wiley Online Library
Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure
causes fetal alcohol spectrum disorder (FASD) in children, but no study had tested this …