The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in
response to genomic instability and DNA damage, thereby providing host defense against …

Artificial intelligence-based protein structure prediction approaches have had a
transformative effect on biomolecular sciences. The predicted protein models in the …

Abstract Ectodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …

Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized
the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy …

A lack of the T cell-inflamed tumor microenvironment limits the efficacy of immune
checkpoint inhibitors (ICIs). Activation of stimulator of interferon genes (STING)-mediated …

Abstract Ecto-nucleotide pyrophosphatases/phosphodiesterases 1 (ENPP1) is a key
enzyme in purinergic signaling pathways responsible for cell-to-cell communications and …

The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of
interferon genes–TANK-binding kinase 1–interferon regulating factor 3 (cGAS-STING-TBK1 …

A series of adamantyl carboxamide derivatives containing sulfonate or sulfonamide moiety
were designed as multitargeted inhibitors of ectonucleotide pyrophosphatases …

Myocardial infarction (MI) results in aberrant cardiac metabolism, but no therapeutics have
been designed to target cardiac metabolism to enhance heart repair. We engineer a …

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) regulates skeletal and soft
tissue mineralization by hydrolyzing nucleotide triphosphates and cyclic nucleotides, and is …