[HTML][HTML] The extracellular matrix: Tools and insights for the “omics” era
The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization …
provides mechanical and chemical cues that orchestrate cellular and tissue organization …
Methods of tissue decellularization used for preparation of biologic scaffolds and in vivo relevance
TJ Keane, IT Swinehart, SF Badylak - Methods, 2015 - Elsevier
Biologic scaffolds composed of extracellular matrix (ECM) are widely used in both preclinical
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …
animal studies and in many clinical applications to repair and reconstruct tissues. Recently …
Extracellular matrix in lung development, homeostasis and disease
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …
Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells
TY Lu, B Lin, J Kim, M Sullivan, K Tobita… - Nature …, 2013 - nature.com
Heart disease is the leading cause of death in the world. Heart tissue engineering holds a
great promise for future heart disease therapy by building personalized heart tissues. Here …
great promise for future heart disease therapy by building personalized heart tissues. Here …
Perfusion decellularization of whole organs
The native extracellular matrix (ECM) outlines the architecture of organs and tissues. It
provides a unique niche of composition and form, which serves as a foundational scaffold …
provides a unique niche of composition and form, which serves as a foundational scaffold …
A review of cellularization strategies for tissue engineering of whole organs
ME Scarritt, NC Pashos, BA Bunnell - Frontiers in bioengineering and …, 2015 - frontiersin.org
With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …
organ engineering were generated from numerous tissues, including the heart, lung, liver …
Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering
Approximately 285 million people worldwide suffer from diabetes, with insulin
supplementation as the most common treatment measure. Regenerative medicine …
supplementation as the most common treatment measure. Regenerative medicine …
Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale
Background Organ engineering is a theoretical alternative to allotransplantation for end-
stage organ failure. Whole-organ scaffolds can be created by detergent perfusion via the …
stage organ failure. Whole-organ scaffolds can be created by detergent perfusion via the …
Naturally derived and synthetic scaffolds for skeletal muscle reconstruction
Skeletal muscle tissue has an inherent capacity for regeneration following injury. However,
severe trauma, such as volumetric muscle loss, overwhelms these natural muscle repair …
severe trauma, such as volumetric muscle loss, overwhelms these natural muscle repair …
In vitro models to study human lung development, disease and homeostasis
The main function of the lung is to support gas exchange, and defects in lung development
or diseases affecting the structure and function of the lung can have fatal consequences …
or diseases affecting the structure and function of the lung can have fatal consequences …