Antioxidants in Alzheimer's disease: Current therapeutic significance and future prospects
Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …
intensifying impairments in cognition, behavior, and memory. Histopathological AD …
[HTML][HTML] The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: A narrative review
E Aaldijk, Y Vermeiren - Ageing Research Reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia, accounting for more than
50 million patients worldwide. Current evidence suggests the exact mechanism behind this …
50 million patients worldwide. Current evidence suggests the exact mechanism behind this …
A comprehensive insight into the mechanisms of dopamine in disrupting Aβ protofibrils and inhibiting Aβ aggregation
Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
Deep eutectic solvents toward the detection and extraction of neurotransmitters: an emerging paradigm for biomedical applications
Neurotransmitters (NTs), the chemical messengers crucial for the proper functioning of the
human brain, have some specific concentration within the human physiological system. Any …
human brain, have some specific concentration within the human physiological system. Any …
Mechanistic insight into the disruption of Tau R3–R4 protofibrils by curcumin and epinephrine: An all-atom molecular dynamics study
The accumulation of Tau protein aggregates is a pathological hallmark of tauopathy,
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …
[HTML][HTML] A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer's disease
Sleep has an important role for long-term memory consolidation. As deficits in learning and
memory are clinical characteristics of Alzheimer's disease (AD), it has been suggested that …
memory are clinical characteristics of Alzheimer's disease (AD), it has been suggested that …
Enhancing the therapeutic effect in Alzheimer's disease drugs: The role of Polypharmacology and Cholinesterase inhibitors
MM Martins, PS Branco, LM Ferreira - ChemistrySelect, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a devastating syndrome that accounts for 60–70% of all
dementia cases, putting an enormous burden on global healthcare and economy …
dementia cases, putting an enormous burden on global healthcare and economy …
Understanding the molecular mechanisms of polyphenol inhibition of amyloid β aggregation
YL Han, HH Yin, C Xiao, MT Bernards… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD) is highly associated with self-aggregation of amyloid β (Aβ)
proteins into fibrils. Inhibition of Aβ aggregation by polyphenols is one of the major …
proteins into fibrils. Inhibition of Aβ aggregation by polyphenols is one of the major …
Mechanisms of melatonin binding and destabilizing the protofilament and filament of tau R3–R4 domains revealed by molecular dynamics simulation
L Zhu, Y Gong, H Lju, G Sun, Q Zhang… - Physical Chemistry …, 2021 - pubs.rsc.org
The accumulation of β-amyloid (Aβ) and tau protein is considered to be an important
pathological characteristic of Alzheimer's disease (AD). Failure of medicine targeting Aβ has …
pathological characteristic of Alzheimer's disease (AD). Failure of medicine targeting Aβ has …
Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by ad-enantiomeric decapeptide rk10
According to clinical studies, the development of Alzheimer's disease (AD) is linked to the
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …
abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as …