Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …

A number of bacteria, and some plants, produce large quantities of indole, which is
widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and …

Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different
levels. Some efflux pumps are constitutively expressed at low levels and contribute to …

The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients
modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by …

Multiple studies have identified conserved genetic pathways and small molecules
associated with extension of lifespan in diverse organisms. However, extending lifespan …

The intestinal epithelium is a highly dynamic structure that rejuvenates in response to acute
stressors and can undergo alterations in cellular composition as animals age. The …

This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …