Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

The'invisible hand'is a term originally coined by Adam Smith in The Theory of Moral
Sentiments to describe the forces of self-interest, competition and supply and demand that …

There are numerous ways that endocytic cargo molecules may be internalized from the
surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of …

Endocytosis occurs at the cell surface and involves internalization of the plasma membrane
(PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in …

An essential property of the plasma membrane of mammalian cells is its plasticity, which is
required for sensing and transmitting of signals, and for accommodating the tensional …

The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

Pancreatic islet β cells secrete insulin in response to nutrient secretagogues, like glucose,
dependent on calcium influx and nutrient metabolism. One of the most intriguing qualities of …

It is estimated that in 2017 there were 451 million people with diabetes worldwide. These
figures are expected to increase to 693 million by 2045; thus, innovative preventative …

The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …

Recent advances in the study of microRNAs indicate that they have an important role in
regulating cellular activities such as proliferation, morphogenesis, apoptosis and …