DNA and RNA contain, next to the four canonical nucleobases, a number of modified
nucleosides that extend their chemical information content. RNA is particularly rich in …

Autophagy is considered as an important mechanism for maintaining homeostasis and
responsible for the degradation of superfluous or potentially toxic components and …

Cytokinin ribosides (N6-substituted adenosine derivatives) have been shown to have
anticancer activity both in vitro and in vivo. This study presents the first systematic analysis of …

Targeting the autophagic process is considered a promising therapeutic strategy in cancer
since a great number of tumors, including melanoma, show high basal levels of protective …

Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been linked
to predisposition to pituitary adenomas. However, the mechanism by which this occurs …

Targeting necroptosis is considered a promising therapeutic strategy in cancer, including
Glioblastoma Multiforme (GBM), one of the most lethal brain tumors. Necroptosis is a …

Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing,
anti-inflammatory, and antipsychotic activity. These compounds also influence platelet …

Glioblastoma (GBM), the most aggressive brain cancer, is highly dependent on the
mevalonate (MVA) pathway for the synthesis of lipid moieties critical for cell proliferation but …

In recent years, modified nucleotides have attracted widespread attention in the field of
chemical biology, biochemistry and beyond. Although some achievements have been made …

Cytokinins (CKs) are a group of phytohormones essential to plant growth and development.
The presence of these N6‐modified adenine derivatives has also been documented in other …