Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration

G Sorrentino, A Comel, F Mantovani, G Del Sal - Mitochondrion, 2014 - Elsevier
Mitochondria are sensitive and efficient organelles that regulate essential biological
processes including: energy metabolism, decoding and transduction of intracellular signals …

Nuclear Tau, p53 and Pin1 regulate PARN-mediated deadenylation and gene expression

J Baquero, S Varriano, M Ordonez, P Kuczaj… - Frontiers in Molecular …, 2019 - frontiersin.org
While nuclear tau plays a role in DNA damage response (DDR) and chromosome
relaxation, the mechanisms behind these functions are not fully understood. Here, we show …

Pin1 liberates the human immunodeficiency virus type-1 (HIV-1): Must we stop it?

H Hou, JZ Wang, BG Liu, T Zhang - Gene, 2015 - Elsevier
Acquired immune deficiency syndrome (AIDS) is mainly caused by the human
immunodeficiency virus type-1 (HIV-1). To our knowledge, this is the first review focusing on …

Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells

H Toko, N Hariharan, MH Konstandin… - Journal of Biological …, 2014 - ASBMB
Autologous c-kit+ cardiac progenitor cells (CPCs) are currently used in the clinic to treat
heart disease. CPC-based regeneration may be further augmented by better understanding …

The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins

N Krishnan, MA Titus, R Thapar - PLoS One, 2014 - journals.plos.org
The peptidyl-prolyl isomerase Pin1 is over-expressed in several cancer tissues is a potential
prognostic marker in prostate cancer, and Pin1 ablation can suppress tumorigenesis in …

Gene expression modifications in Wharton's Jelly mesenchymal stem cells promoted by prolonged in vitro culturing

V Gatta, M D'Aurora, P Lanuti, L Pierdomenico… - BMC genomics, 2013 - Springer
Background It has been demonstrated that the umbilical cord matrix, represented by the
Wharton's Jelly (WJ), contains a great number of mesenchymal stem cells (MSCs) …

[HTML][HTML] Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles

C Ettelaie, MEW Collier, S Featherby… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The exposure and release of TF is regulated by post-translational modifications of its
cytoplasmic domain. Here, the potential of Pin1 to interact with the cytoplasmic domain of TF …

Pin1-based diagnostic and therapeutic strategies for breast cancer

JZ Wang, BG Liu, Y Zhang - Pharmacological Research, 2015 - Elsevier
Pin1 is the only known cis-to-trans isomerase that recognizes the phosphorylated pThr/pSer-
Pro motifs in many signaling molecules, playing unique roles in the pathogenesis of breast …

Pin1 in cardiovascular dysfunction: a potential double-edge role

JZ Wang, GJ Liu, ZY Li, XH Wang - International journal of cardiology, 2016 - Elsevier
Backgrounds Our lab focused on the structural and functional properties of Pin1, which is the
only known cis–trans isomerase regulating pSer/pThr–Pro motifs in proteins and facilitates …

Pin1 is related with clinical stage of papillary thyroid carcinoma

L Jiang, H Chu, H Zheng - World Journal of Surgical Oncology, 2016 - Springer
Background The context and aim of this article was to investigate whether the expression
level of Pin1 was in association with the clinical stage of papillary thyroid carcinomas …