Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA. 5 Omicron variant in mice

SM Scheaffer, D Lee, B Whitener, B Ying, K Wu… - Nature medicine, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

PJ Halfmann, S Iida, K Iwatsuki-Horimoto, T Maemura… - Nature, 2022 - nature.com
The recent emergence of B. 1.1. 529, the Omicron variant,, has raised concerns of escape
from protection by vaccines and therapeutic antibodies. A key test for potential …

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

RE Chen, X Zhang, JB Case, ES Winkler, Y Liu… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …

Viral infection neutralization tests: A focus on severe acute respiratory syndrome‐coronavirus‐2 with implications for convalescent plasma therapy

D Focosi, F Maggi, P Mazzetti… - Reviews in medical …, 2021 - Wiley Online Library
Viral neutralization tests (VNTs) have long been considered old‐fashioned tricks in the
armamentarium of fundamental virology, with laboratory implementation for a limited array of …

[HTML][HTML] The SARS-CoV-2 B. 1.1. 529 Omicron virus causes attenuated infection and disease in mice and hamsters

M Diamond, P Halfmann, T Maemura… - Research …, 2021 - ncbi.nlm.nih.gov
Despite the development and deployment of antibody and vaccine countermeasures, rapidly-
spreading SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein …

[HTML][HTML] Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

B Ying, SM Scheaffer, B Whitener, CY Liang… - Cell, 2022 - cell.com
The large number of spike substitutions in Omicron lineage variants (BA. 1, BA. 1.1., and BA.
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …

[HTML][HTML] Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B. 1.1. 529 infection in mice

B Ying, SM Scheaffer, B Whitener, CY Liang… - BioRxiv, 2022 - ncbi.nlm.nih.gov
Abstract The B. 1.1. 529 Omicron variant jeopardizes vaccines designed with early
pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna …

SARS-CoV-2 mRNA vaccines elicit different responses in immunologically naïve and pre-immune humans

D Forgacs, H Jang, RB Abreu, HB Hanley… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic continues, the authorization of vaccines for emergency use has
been crucial in slowing down the rate of infection and transmission of the SARS-CoV-2 virus …

Nature of Acquired Immune Responses, Epitope Specificity and Resultant Protection from SARS-CoV-2

RM Gorczynski, RA Lindley, EJ Steele… - Journal of Personalized …, 2021 - mdpi.com
The primary global response to the SARS-CoV-2 pandemic has been to bring to the clinic as
rapidly as possible a number of vaccines that are predicted to enhance immunity to this viral …

Evaluation of humoral immune response after SARS-CoV-2 vaccination using two binding antibody assays and a neutralizing antibody assay

M Nam, JD Seo, HW Moon, H Kim, M Hur… - Microbiology …, 2021 - Am Soc Microbiol
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have been developed and administered to mitigate the coronavirus disease 2019 (COVID …