Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated
fatty acid substrates to produce biologically active lipid mediators including eicosanes and …

Exposure to high altitudes generates a decrease in the partial pressure of oxygen, triggering
a hypobaric hypoxic condition. This condition produces pathophysiologic alterations in an …

Modulation of the vascular smooth‐muscle‐cell (vSMC) phenotype from a quiescent
'contractile'phenotype to a proliferative 'synthetic'phenotype has been implicated in vascular …

Hypoxia contributes to the pathogenesis of various human diseases, including pulmonary
artery hypertension (PAH), stroke, myocardial or cerebral infarction, and cancer. For …

Pulmonary hypertension is a multifactorial disease characterized by sustained elevation of
pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP). Central to the …

Conventional smoking is known to both increase susceptibility to infection and drive
inflammation within the lungs. Recently, smokers have been found to be at higher risk of …

Lipoxygenase (LOX) pathway leads to the formation of leukotrienes and also catalyses the
conversion of arachidonic acid (AA) to hydroperoxyeicosatetraenoic acids that are then …

High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating
several mechanisms at the physiological, cellular, and molecular levels and triggering the …