Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Oxidative stress results from the disruption of the redox system marked by a notable
overproduction of reactive oxygen species. There are four major sources of reactive oxygen …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

To define cellular mechanisms underlying kidney function and failure, the KPMP analyzes
biopsy tissue in a multicenter research network to build cell-level process maps of the …

Glomerular endothelial cell (GEnC) dysfunction is important in the pathogenesis of
glomerular sclerotic diseases, including Focal Segmental Glomerulosclerosis (FSGS) and …

As adult podocytes cannot adequately proliferate following depletion in disease states, there
has been interest in the potential role of progenitors in podocyte repair and regeneration. To …

Podocytes (terminally differentiated epithelial cells of the glomeruli) play a key role in the
maintenance of glomerular structure and permeability and in the incipiency of various renal …

In kidney transplantations, pathologists evaluate the architecture of both glomeruli,
interstitium and tubules to assess the nephron status. An accurate assessment of …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …