Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses

AD Garg, P Agostinis - Immunological reviews, 2017 - Wiley Online Library
The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

Metal drugs and the anticancer immune response

B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Immunogenic cell death and immunotherapy of multiple myeloma

A Serrano-del Valle, A Anel, J Naval… - Frontiers in Cell and …, 2019 - frontiersin.org
Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a
wide variety of human tumors. For many years, apoptosis has been considered a non …

Molecular and translational classifications of DAMPs in immunogenic cell death

AD Garg, L Galluzzi, L Apetoh, T Baert… - Frontiers in …, 2015 - frontiersin.org
The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides developing direct …

Origin and consequences of necroinflammation

M Sarhan, WG Land, W Tonnus… - Physiological …, 2018 - journals.physiology.org
When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Realizing the clinical potential of immunogenic cell death in cancer chemotherapy and radiotherapy

BL Rapoport, R Anderson - International journal of molecular sciences, 2019 - mdpi.com
Immunogenic cell death (ICD), which is triggered by exposure of tumor cells to a limited
range of anticancer drugs, radiotherapy, and photodynamic therapy, represents a recent …

Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian …

AD Garg, D De Ruysscher, P Agostinis - Oncoimmunology, 2016 - Taylor & Francis
The emerging role of the cancer cell-immune cell interface in shaping tumorigenesis/
anticancer immunotherapy has increased the need to identify prognostic biomarkers …

Preclinical and clinical evidence of immune responses triggered in oncologic photodynamic therapy: clinical recommendations

I Beltrán Hernández, Y Yu, F Ossendorp… - Journal of clinical …, 2020 - mdpi.com
Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a
photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon …

Physical plasma-treated saline promotes an immunogenic phenotype in CT26 colon cancer cells in vitro and in vivo

E Freund, KR Liedtke, J van der Linde… - Scientific reports, 2019 - nature.com
Metastatic colorectal cancer is the fourth most common cause of cancer death. Current
options in palliation such as hyperthermic intraperitoneal chemotherapy (HIPEC) present …

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro

D Wernitznig, K Kiakos, G Del Favero, N Harrer… - Metallomics, 2019 - academic.oup.com
The ruthenium complex sodium trans-[tetrachloridobis (1 H-indazole) ruthenate
(iii)](KP1339/IT-139) showed preclinical activity in a variety of in vivo tumor models including …