Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …
The treatment options against infections caused by multiple drug-resistant bacteria are …
Membrane Efflux Pumps of Pathogenic Vibrio Species: Role in Antimicrobial Resistance and Virulence
Infectious diseases caused by bacterial species of the Vibrio genus have had considerable
significance upon human health for centuries. V. cholerae is the causative microbial agent of …
significance upon human health for centuries. V. cholerae is the causative microbial agent of …
Proton-driven alternating access in a spinster lipid transporter
Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P)
across cellular membranes. In humans, Spns2 functions as the main S1P transporter in …
across cellular membranes. In humans, Spns2 functions as the main S1P transporter in …
Molecular docking and dynamics simulation approach of Camellia sinensis leaf extract derived compounds as potential cholinesterase inhibitors
The tea plant (Camellia sinensis) belongs to the family Theaceae and contains many
phytochemicals that are effective against various diseases, including neurodegenerative …
phytochemicals that are effective against various diseases, including neurodegenerative …
[HTML][HTML] Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family
Proteins from the small multidrug resistance (SMR) family are frequently associated with
horizontally transferred multidrug resistance gene arrays found in bacteria from wastewater …
horizontally transferred multidrug resistance gene arrays found in bacteria from wastewater …
Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB
J Wilhelm, KM Pos - Microbiology, 2024 - microbiologyresearch.org
Gram-negative bacterial members of the Resistance Nodulation and cell Division (RND)
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …
superfamily form tripartite efflux pump systems that span the cell envelope. One of the …
Structural and functional characteristics of the tripartite ABC transporter
U Okada, S Murakami - Microbiology, 2022 - microbiologyresearch.org
ATP-binding cassette (ABC) transporters are one of the largest protein superfamilies and are
found in all living organisms. These transporters use the energy from ATP binding and …
found in all living organisms. These transporters use the energy from ATP binding and …
Vacuolar proteomic analysis reveals tonoplast transporters for accumulation of citric acid and sugar in citrus fruit
Z Mao, Y Wang, M Li, S Zhang, Z Zhao, Q Xu… - Horticulture …, 2024 - academic.oup.com
Vacuole largely dictates the fruit taste and flavor, as most of the sugars and organic acids
are stored in the vacuoles of the fruit. However, difficulties associated with vacuole …
are stored in the vacuoles of the fruit. However, difficulties associated with vacuole …
Identification of potential candidate vaccines against Mycobacterium ulcerans based on the major facilitator superfamily transporter protein
TZ Ishwarlall, VT Adeleke, L Maharaj… - Frontiers in …, 2022 - frontiersin.org
Buruli ulcer is a neglected tropical disease that is characterized by non-fatal lesion
development. The causative agent is Mycobacterium ulcerans (M. ulcerans). There are no …
development. The causative agent is Mycobacterium ulcerans (M. ulcerans). There are no …
The alternating access mechanism in mammalian multidrug resistance transporters and their bacterial homologs
Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC)
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …