Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Retinal pigment epithelial (RPE) cells form a monolayer between the neuroretina and
choroid. It has multiple important functions, including acting as outer blood-retina barrier …

Macroautophagy decreases with age, and this change is considered a hallmark of the aging
process. It remains unknown whether mitophagy, the essential selective autophagic …

Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene
when overexpressed and accelerates aging when deleted in mice. Previously, we showed …

Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive
retinal degenerative disease characterized by dysfunction and loss of retinal pigment …

Years of important research has revealed that cells heavily invest in regulating their size.
Nevertheless, it has remained unclear why accurate size control is so important. Our recent …

Retinal pigment epithelium (RPE) damage is a major factor in age-related macular
degeneration (AMD). The RPE in AMD shows mitochondrial dysfunction suggesting an …

Purpose: This study used high-throughput RNA sequencing (RNA-Seq) and bioinformatics
analysis to investigate the altered transcriptome profile of aging lacrimal glands in mice that …

The corneal epithelium is located at the outermost layer of the ocular surface and
continuously exposed to environmental factors, such as ultraviolet (UV) radiation from …

Non-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause
in the elderly. Clinical and experimental evidence supports that early alterations in macular …