Towards revealing the functions of all genes in plants
The great recent progress made in identifying the molecular parts lists of organisms
revealed the paucity of our understanding of what most of the parts do. In this review, we …
revealed the paucity of our understanding of what most of the parts do. In this review, we …
Machine learning in enzyme engineering
Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …
BUSCA: an integrative web server to predict subcellular localization of proteins
Here, we present BUSCA (http://busca. biocomp. unibo. it), a novel web server that
integrates different computational tools for predicting protein subcellular localization …
integrates different computational tools for predicting protein subcellular localization …
Determining microbial products and identifying molecular targets in the human microbiome
Human-associated microbes are the source of many bioactive microbial products (proteins
and metabolites) that play key functions both in human host pathways and in microbe …
and metabolites) that play key functions both in human host pathways and in microbe …
[HTML][HTML] A large-scale evaluation of computational protein function prediction
Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …
genomes rapidly grows, the overwhelming majority of protein products can only be …
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …
is the assignment of function to proteins. While molecular experiments provide the most …
The role of ontologies in biological and biomedical research: a functional perspective
R Hoehndorf, PN Schofield… - Briefings in …, 2015 - academic.oup.com
Ontologies are widely used in biological and biomedical research. Their success lies in their
combination of four main features present in almost all ontologies: provision of standard …
combination of four main features present in almost all ontologies: provision of standard …
deepNF: deep network fusion for protein function prediction
Motivation The prevalence of high-throughput experimental methods has resulted in an
abundance of large-scale molecular and functional interaction networks. The connectivity of …
abundance of large-scale molecular and functional interaction networks. The connectivity of …
[HTML][HTML] Optimizing cellulase production from Aspergillus flavus using response surface methodology and machine learning models
The study aims to optimize cellulase (CMCase) production by Aspergillus flavus using wheat
straw, an abundantly available lignocellulosic waste, as a substrate. Three parameters, ie …
straw, an abundantly available lignocellulosic waste, as a substrate. Three parameters, ie …
GOLabeler: improving sequence-based large-scale protein function prediction by learning to rank
Abstract Motivation Gene Ontology (GO) has been widely used to annotate functions of
proteins and understand their biological roles. Currently only< 1% of> 70 million proteins in …
proteins and understand their biological roles. Currently only< 1% of> 70 million proteins in …