B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports …
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP- ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …
C Bubici, S Papa - British journal of pharmacology, 2014 - Wiley Online Library
The JNKs are master protein kinases that regulate many physiological processes, including inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
Productive humoral responses require that naive B cells and their differentiated progeny move among distinct micro-environments. In this review, we discuss how studies are …
S Vyas, M Chesarone-Cataldo, T Todorova… - Nature …, 2013 - nature.com
The poly (ADP-ribose) polymerase (PARP) family of proteins use NAD+ as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under …
F Rosenthal, KLH Feijs, E Frugier, M Bonalli… - Nature structural & …, 2013 - nature.com
ADP-ribosylation is an important post-translational protein modification (PTM) that regulates diverse biological processes. ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10, also …