PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

R Gupte, Z Liu, WL Kraus - Genes & development, 2017 - genesdev.cshlp.org
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …

The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions

AR Fehr, SA Singh, CM Kerr, S Mukai… - Genes & …, 2020 - genesdev.cshlp.org
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

Initial B cell activation induces metabolic reprogramming and mitochondrial remodeling

LR Waters, FM Ahsan, DM Wolf, O Shirihai, MA Teitell - IScience, 2018 - cell.com
B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and
supporting the activation of T cells. Little is known about how global metabolism supports …

ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease

B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

SH Cho, AL Raybuck, K Stengel, M Wei, TC Beck… - Nature, 2016 - nature.com
Germinal centres (GCs) promote humoral immunity and vaccine efficacy. In GCs, antigen-
activated B cells proliferate, express high-affinity antibodies, promote antibody class …

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

H Iwata, C Goettsch, A Sharma, P Ricchiuto… - Nature …, 2016 - nature.com
Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …

JNK signalling in cancer: in need of new, smarter therapeutic targets

C Bubici, S Papa - British journal of pharmacology, 2014 - Wiley Online Library
The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …

Metabolic regulation of the immune humoral response

M Boothby, RC Rickert - Immunity, 2017 - cell.com
Productive humoral responses require that naive B cells and their differentiated progeny
move among distinct micro-environments. In this review, we discuss how studies are …

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

S Vyas, M Chesarone-Cataldo, T Todorova… - Nature …, 2013 - nature.com
The poly (ADP-ribose) polymerase (PARP) family of proteins use NAD+ as their substrate to
modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under …

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases

F Rosenthal, KLH Feijs, E Frugier, M Bonalli… - Nature structural & …, 2013 - nature.com
ADP-ribosylation is an important post-translational protein modification (PTM) that regulates
diverse biological processes. ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10, also …