Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …

Several studies have indicated that the use of antihypertensive medications may influence
the incidence of bladder/kidney cancer, with some scholars refuting any such association …

Hypertension is the most prevalent comorbidity in cancer patients. Consequently, many
cancer patients are prescribed antihypertensive drugs before cancer diagnosis or during …

Importance While originally approved for the management of heart failure, hypertension, and
edema, spironolactone is commonly used off label in the management of acne, hidradenitis …

The cancer stem cell (CSC) model suggests that a subpopulation of cells within the tumor,
the CSCs, is responsible for cancer relapse and metastasis formation. CSCs hold unique …

The expression status of mineralocorticoid receptor (MR) and its biological significance in
human urothelial carcinoma remain unknown. The present study aimed to determine the …

The biological or clinical significance of mineralocorticoid receptor (MR) in urothelial cancer
remains largely unknown. The present study aimed to determine the functional role of MR in …

Background Spironolactone, a cheap effective diuretic used to manage hypertension and
heart failure, also has anti-androgenic effects through its non-selective binding to steroid …

Background For decades, conflicting results were published regarding the increased risk of
Prostate cancer (PCa) among calcium channel blocker (CCB) users. Objective We aimed to …

Background/purpose Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease
affecting oral health. Evidence shows possible association between T1DM and periodontal …