Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

The ability of mitochondria to capture Ca2+ ions has important functional implications for
cells, because mitochondria shape cellular Ca2+ signals by acting as a Ca2+ buffer and …

Sorafenib has been used to treat advanced hepatocellular carcinoma (HCC), but the
underlying molecular mechanisms remain controversial and why some patients do not …

Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the
hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as …

Leucine zipper-EF-hand-containing transmembrane protein1 (LETM1) is located in the
mitochondrial inner membrane and is defective in Wolf-Hirschhorn syndrome. LETM1 …

Copy number variations (CNVs) have been demonstrated as crucial substrates for evolution,
adaptation and breed formation. Chinese indigenous cattle breeds exhibit a broad …

The selective autophagy of damaged mitochondria is called mitophagy. Mitochondrial
dysfunction, mitophagy, and apoptosis have been suggested to be interrelated in various …

Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-
Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing …

Leucine zipper/EF‑hand‑containing transmembrane protein 1 (LETM1) has been identified
as the gene responsible for Wolf‑Hirschhorn syndrome (WHS), which is characterized by …