Myasthenia gravis (MG) is the prototypical autoimmune disorder caused by specific
autoantibodies at the neuromuscular junction. Broad-based immunotherapies, such as …

Systemic autoimmunity is a complex disease process that results from a loss of
immunological tolerance characterized by the inability of the immune system to discriminate …

Autoimmunity occurs when an adaptive immune response is directed against a self-antigen.
As such, autoimmune reactions associated with the production of autoantibodies are …

Antibody‐secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant
function of ASCs is related to a number of disease states, including autoimmune diseases …

In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a
compelling mechanism underlying autoimmune diseases. The discovery of T regulatory …

Autoimmune diseases represent a severe personal and healthcare problem that seeks
novel therapeutic solutions. Mesenchymal stem cells (MSCs) are multipotent cells with …

Despite advances in understanding systemic lupus erythematosus (SLE) pathogenesis,
most clinical trials of new targeted therapies have been met with disappointment. The type I …

The objective of the study was to evaluate prospectively real-life experience on the effect of
belimumab on patients with active systemic lupus erythematosus (SLE). Forty-eight patients …

The approval of anti-B cell activating factor therapy and an increasing body of open studies
with rituximab as well as subset studies and secondary analysis of the Efficacy and Safety of …

B and T cells collaborate to drive autoimmune disease (AID). Historically, B-and T-cell (B–T
cell) co-interaction was targeted through different pathways such as alemtuzumab …