Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are
calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive …

Aortic stenosis is a common, potentially fatal condition that is set to become an increasing
public health burden. Once symptoms develop, there is an inexorable deterioration with a …

Background: Valvular calcification is central to the pathogenesis and progression of aortic
stenosis, with preclinical and observational studies suggesting that bone turnover and …

Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …

Bone never forms without vascular interactions. This simple statement of fact does not
adequately reflect the physiological and pharmacological implications of the relationship …

The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …

Traditional imaging modalities such as computed tomography, although perfectly adept at
identifying and quantifying advanced calcification, cannot detect the early stages of this …

Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical
practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic …