[HTML][HTML] Personalizing Therapy Outcomes through Mitogen-Activated Protein Kinase Pathway Inhibition in Non-Small Cell Lung Cancer

H Alsharoh, P Chiroi, E Isachesku, RA Tanasa, OL Pop… - Biomedicines, 2024 - mdpi.com
Lung cancer (LC) is a highly invasive malignancy and the leading cause of cancer-related
deaths, with non-small cell lung cancer (NSCLC) as its most prevalent histological subtype …

[HTML][HTML] Decoding PTEN regulation in clear cell renal cell carcinoma: Pathway for biomarker discovery and therapeutic insights

 Alves, R Medeiros, AL Teixeira, F Dias - Biochimica et Biophysica Acta …, 2024 - Elsevier
Renal cell carcinoma is the most common adult renal solid tumor and the deadliest
urological cancer, with clear cell renal cell carcinoma (ccRCC) being the predominant …

Exploring the modulation of TLR4 and its associated ncRNAs in cancer immunopathogenesis, with an emphasis on the therapeutic implications and mechanisms …

MY Alshahrani, EF Oghenemaro, J Rizaev, A Kyada… - Human Immunology, 2025 - Elsevier
This study provides an in-depth analysis of the pathogenic relevance, therapeutic
implications, and mechanisms of treatment resistance associated with TLR4 and its ncRNAs …

Tumor-derived lncRNAs; Behind-the-scenes mediators that modulate the immune system and play a role in cancer pathogenesis

SIS Al-Hawary, RO Saleh, SG Taher, SM Ahmed… - … -Research and Practice, 2024 - Elsevier
Having been involved in complex cellular regulatory networks and cell-to-cell
communications, non-coding RNAs (lncRNAs) have become functional carriers that transmit …

[HTML][HTML] Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis

VK Kashyap, BP Sharma, D Pandey, AK Singh… - Cells, 2024 - mdpi.com
Metarrestin (ML246) is a first-in-class pyrrole–pyrimidine-derived small molecule that
selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear …

MicroRNA networks in prolactinoma tumorigenesis: a scoping review

SG Rad, FN Orang, MA Shadbad - Cancer Cell International, 2024 - Springer
Background Prolactinoma is the leading type of pituitary adenoma. Aside from the mass-like
effect of prolactinoma, its hormonal effect is the main pathological cause of endocrine …

[HTML][HTML] Advancing the next generation of cancer treatment with circular RNAs in CAR-T cell therapy

S Huang, J Xu, N Baran, W Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment
of hematological malignancies. However, its effectiveness against solid tumors remains …

Unleashing nanotechnology to redefine tumor-associated macrophage dynamics and non-coding RNA crosstalk in breast cancer

H Patni, R Chaudhary, A Kumar - Nanoscale, 2024 - pubs.rsc.org
Breast cancer is a significant global health issue. Tumor-associated macrophages (TAMs)
are crucial in influencing the tumor microenvironment and the progression of the disease …

[HTML][HTML] Long Non-Coding RNAs in Malignant Human Brain Tumors: Driving Forces Behind Progression and Therapy

D Pei, D Zhang, Y Guo, H Chang, H Cui - International Journal of …, 2025 - mdpi.com
Long non-coding RNAs (lncRNAs) play a pivotal role in regulating gene expression and are
critically involved in the progression of malignant brain tumors, including glioblastoma …

Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update

MA Diamantopoulos, PG Adamopoulos… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Non-coding RNAs (ncRNAs) comprise a heterogeneous cluster of
RNA molecules. Emerging evidence suggests their involvement in various aspects of …