Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …

Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent 2 of the largest sources
of death and disability in the United States. Recent studies have identified TBI as a potential …

The innate immune system is the critical first line of defense against infectious and sterile
insults. A cell's ability to sense these insults relies on a series of germline-encoded …

Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …