Cellular responses to DNA damage
CJ Norbury, ID Hickson - Annual review of pharmacology and …, 2001 - annualreviews.org
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …
agents. These agents can either be exogenous or formed within cells. Environmental DNA …
Toward maintaining the genome: DNA damage and replication checkpoints
KA Nyberg, RJ Michelson, CW Putnam… - Annual review of …, 2002 - annualreviews.org
▪ Abstract DNA checkpoints play a significant role in cancer pathology, perhaps most notably
in maintaining genome stability. This review summarizes the genetic and molecular …
in maintaining genome stability. This review summarizes the genetic and molecular …
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR)
and AMP-activated protein kinase (AMPK) are central to cellular metabolism and cell …
and AMP-activated protein kinase (AMPK) are central to cellular metabolism and cell …
Mrc1 transduces signals of DNA replication stress to activate Rad53
Cells experiencing DNA replication stress activate a response pathway that delays entry into
mitosis and promotes DNA repair and completion of DNA replication. The protein kinases …
mitosis and promotes DNA repair and completion of DNA replication. The protein kinases …
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses
Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined
as a eukaryotic single‐stranded DNA binding (SSB) protein essential for the in vitro …
as a eukaryotic single‐stranded DNA binding (SSB) protein essential for the in vitro …
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
Histone lysine methylation is a key regulator of gene expression and heterochromatin
function, but little is known as to how this modification impinges on other chromatin activities …
function, but little is known as to how this modification impinges on other chromatin activities …
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
Cells respond to DNA damage by activating a network of signaling pathways that control cell
cycle progression and DNA repair. Genetic studies in yeast suggested that several …
cycle progression and DNA repair. Genetic studies in yeast suggested that several …
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA
V Ellison, B Stillman - PLoS biology, 2003 - journals.plos.org
The cellular pathways involved in maintaining genome stability halt cell cycle progression in
the presence of DNA damage or incomplete replication. Proteins required for this pathway …
the presence of DNA damage or incomplete replication. Proteins required for this pathway …
[PDF][PDF] The PCNA-RFC families of DNA clamps and clamp loaders
J Majka, PMJ Burgers - Progress in nucleic acid …, 2004 - burgerslab.biochem.wustl.edu
Progress in Nucleic Acid Research Copyright 2004, Elsevier Inc. and Molecular Biology, Vol.
78 227 All rights reserved. 0079-6603/04 $35.00 modeling. Its modification by ubiquitin …
78 227 All rights reserved. 0079-6603/04 $35.00 modeling. Its modification by ubiquitin …
Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complex
ER Parrilla-Castellar, SJH Arlander, L Karnitz - DNA repair, 2004 - Elsevier
Genotoxic stress activates checkpoint signaling pathways that block cell cycle progression,
trigger apoptosis, and regulate DNA repair. Studies in yeast and humans have shown that …
trigger apoptosis, and regulate DNA repair. Studies in yeast and humans have shown that …