Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
T McLaughlin, A Medina, J Perkins, M Yera… - Molecular …, 2022 - Springer
Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …
self-reparation and regeneration in mammals, is under cumulative environmental stress due …
[HTML][HTML] Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) characterized by focal inflammatory lesions and prominent demyelination. Even …
(CNS) characterized by focal inflammatory lesions and prominent demyelination. Even …
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology
Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic
strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors …
strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors …
A penalized integrative deep neural network for variable selection among multiple omics datasets
Deep learning has been increasingly popular in omics data analysis. Recent works
incorporating variable selection into deep learning have greatly enhanced the model's …
incorporating variable selection into deep learning have greatly enhanced the model's …
Compound heterozygous variants in SLC45A1 might cause syndromic intellectual disability by localization failure and activity attenuation in cells
C Zhou, J Zhu, P Tang, J Zhu, X Zhu, L Yang… - Clinical …, 2024 - Wiley Online Library
Intellectual disability (ID) is a kind of nervous developmental disorder and affects more than
1% of people worldwide. SLC45A1 as a transmembrane protein is implicated in the …
1% of people worldwide. SLC45A1 as a transmembrane protein is implicated in the …
Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis
A Mohammadnejad, J Baumbach, W Li, J Lund… - Journal of Psychiatric …, 2021 - Elsevier
Cognitive impairment is the most prominent symptom in neurodegenerative disorders
affecting quality of life and mortality. However, despite years of research, the molecular …
affecting quality of life and mortality. However, despite years of research, the molecular …
[HTML][HTML] Identifying genetic variants regulating MGMT gene expression-A study in monozygotic Danish twins
A Mohammadnejad, M Soerensen, J Mengel-From… - Genomics, 2023 - Elsevier
Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA
Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene …
Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene …
sMAP: An interactive microarray data analysis tool for early-stage researchers
Microarray data enables biologists to extract differentially expressed genes (DEGs) across
multiple phenotypes. While several pipelines and tools exist to perform microarray data …
multiple phenotypes. While several pipelines and tools exist to perform microarray data …
PDE4 gene inhibition: a novel approach to treat demyelinating disorders
M Schepers - 2023 - cris.maastrichtuniversity.nl
Neurological disorders such as MS, spinal cord injury, and nerve damage can result in
damage to the myelin sheath, the protective layer around nerve fibers in the body. This leads …
damage to the myelin sheath, the protective layer around nerve fibers in the body. This leads …