Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
FG Spinale - Physiological reviews, 2007 - journals.physiology.org
It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …
Fibrosis imaging: current concepts and future directions
Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …
Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis
Objectives: The aim of this study was to test whether blood monocytosis in mice with
atherosclerosis affects infarct healing. Background: Monocytes are cellular protagonists of …
atherosclerosis affects infarct healing. Background: Monocytes are cellular protagonists of …
The history of matrix metalloproteinases: milestones, myths, and misperceptions
Since the discovery of tadpole collagenase in 1962, the matrix metalloproteinase (MMP)
family has emerged as a significant proteinase group with recognized effects on the …
family has emerged as a significant proteinase group with recognized effects on the …
Multimodality imaging assessment of myocardial fibrosis
Myocardial fibrosis, seen in ischemic and nonischemic cardiomyopathies, is associated with
adverse cardiac outcomes. Noninvasive imaging plays a key role in early identification and …
adverse cardiac outcomes. Noninvasive imaging plays a key role in early identification and …
Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction
F Leuschner, P Panizzi, I Chico-Calero… - Circulation …, 2010 - Am Heart Assoc
Rationale: Monocytes recruited to ischemic myocardium originate from a reservoir in the
spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling …
spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling …
Membrane-associated matrix proteolysis and heart failure
FG Spinale, JS Janicki, MR Zile - Circulation research, 2013 - Am Heart Assoc
The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural
proteins, signaling molecules, and proteases. Changes in the overall integrity and …
proteins, signaling molecules, and proteases. Changes in the overall integrity and …
The role of matrix metalloproteinases in development, repair, and destruction of the lungs
AY Hendrix, F Kheradmand - … in molecular biology and translational science, 2017 - Elsevier
Normal gas exchange after birth requires functional lung alveolar units that are lined with
epithelial cells, parts of which are intricately fused with microvascular capillaries. A …
epithelial cells, parts of which are intricately fused with microvascular capillaries. A …
Molecular imaging of cardiac remodelling after myocardial infarction
D Curley, B Lavin Plaza, AM Shah… - Basic research in …, 2018 - Springer
Myocardial infarction and subsequent heart failure is a major health burden associated with
significant mortality and morbidity in western societies. The ability of cardiac tissue to …
significant mortality and morbidity in western societies. The ability of cardiac tissue to …
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo
Background—Fluorescence imaging of the heart is currently limited to invasive ex vivo or in
vitro applications. We hypothesized that the adaptation of advanced transillumination and …
vitro applications. We hypothesized that the adaptation of advanced transillumination and …