Epilepsy comprises a group of disorders characterized by the periodic occurrence of
seizures, and pathologic specimens from patients with temporal lobe epilepsy demonstrate …

Epilepsy, affecting about 1% of the population, comprises a group of disorders of the brain
characterized by the periodic and unpredictable occurrence of seizures. Epilepsy is a major …

We describe members of 4 kindreds with a previously unrecognized syndrome
characterized by seizures, sensorineural deafness, ataxia, mental retardation, and …

The Kir4. 1 channel is crucial for the maintenance of the resting membrane potential of glial
cells, and it is believed to play a main role in the homeostasis of extracellular potassium. To …

Recent studies have implicated glial cells in modulation of synaptic transmission, so it is
plausible that glial cells may have a functional role in the hyperexcitability characteristic of …

A number of ion channels and transporters are expressed in both the inner ear and kidney.
In the inner ear, K+ cycling and endolymphatic K+, Na+, Ca2+, and pH homeostasis are …

Ongoing rhythmic neuronal activity in the ventral respiratory group (VRG) of the brain stem
results in periodic changes of extracellular K+. To estimate the involvement of the weakly …

K+ channels fulfill roles spanning from the control of excitability to the regulation of
transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P …

Endolymphatic potential (EP) is the main driving force behind the sensory transduction of
hearing, and K+ is the main charge carrier. Kir5. 1 is a K+ transporter that plays a significant …

Inwardly rectifying potassium channel Kir4. 1 is critical for glial function, control of neuronal
excitability, and systemic K+ homeostasis. Novel mutations in Kir4. 1 have been associated …