Dendritic cell physiology and function in the eye
The eye and the brain are immunologically privileged sites, a property previously attributed
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …
Macrophage physiology in the eye
The eye is a complex sensory organ composed of a range of tissue types including epithelia,
connective tissue, smooth muscle, vascular and neural tissue. While some components of …
connective tissue, smooth muscle, vascular and neural tissue. While some components of …
Vascular endothelial growth factor promotes fibrosis resolution and repair in mice
Background & Aims Vascular endothelial growth factor (VEGF)− induced angiogenesis is
implicated in fibrogenesis and portal hypertension. However, the function of VEGF in fibrosis …
implicated in fibrogenesis and portal hypertension. However, the function of VEGF in fibrosis …
Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis
SM Leal Jr, S Cowden, YC Hsia, MA Ghannoum… - PLoS …, 2010 - journals.plos.org
Aspergillus species are a major worldwide cause of corneal ulcers, resulting in visual
impairment and blindness in immunocompetent individuals. To enhance our understanding …
impairment and blindness in immunocompetent individuals. To enhance our understanding …
Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1
To examine the role of caspase-1 and the NLRC4 inflammasome during bacterial infection,
C57BL/6, IL-1β−/−, caspase-1−/−, and NLRC4−/− mouse corneas were infected with ExoS/T …
C57BL/6, IL-1β−/−, caspase-1−/−, and NLRC4−/− mouse corneas were infected with ExoS/T …
Influenza infection suppresses NADPH oxidase–dependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant …
K Sun, DW Metzger - The Journal of Immunology, 2014 - journals.aai.org
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a leading contributor to
mortality during recent influenza pandemics. The mechanism for this influenza-induced …
mortality during recent influenza pandemics. The mechanism for this influenza-induced …
TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and-independent pathways
Y Sun, M Karmakar, S Roy, RT Ramadan… - The Journal of …, 2010 - journals.aai.org
Pseudomonas aeruginosa is a major cause of blindness and visual impairment in the United
States and worldwide. Using a murine model of keratitis in which abraded corneas are …
States and worldwide. Using a murine model of keratitis in which abraded corneas are …
Identification of macrophages in normal and injured mouse tissues using reporter lines and antibodies
Reliable tools for macrophage identification in mouse tissues are critical for studies
investigating inflammatory and reparative responses. Transgenic reporter mice and anti …
investigating inflammatory and reparative responses. Transgenic reporter mice and anti …
ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival
Y Sun, M Karmakar, PR Taylor, A Rietsch… - The Journal of …, 2012 - journals.aai.org
Pseudomonas aeruginosa is a leading cause of blinding corneal ulcers worldwide. To
determine the role of type III secretion in the pathogenesis of P. aeruginosa keratitis, corneas …
determine the role of type III secretion in the pathogenesis of P. aeruginosa keratitis, corneas …
[HTML][HTML] Dendritic cell–epithelium interplay is a determinant factor for corneal epithelial wound repair
The functions of intraepithelial dendritic cells (DCs) are critical for mucosal innate and
adaptive immunity, but little is known about the role of tissue-specific DCs in epithelial …
adaptive immunity, but little is known about the role of tissue-specific DCs in epithelial …