Fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) in
basement membranes and interstitial tissues, resulting from increased synthesis or …

The adult respiratory distress syndrome (ARDS) is characterized by extended inflammatory
processes in the lung microvascular, interstitial, and alveolar compartments, resulting in …

To elucidate the pathophysiology of idiopathic pulmonary fibrosis (IPF), we examined
procoagulant (tissue factor: TF), fibrinolytic (tissue type plasminogen activator: t-PA and …

Background: Fibrin deposition is a hallmark of pneumonia. To determine the kinetics of
alterations in local coagulation and fibrinolysis in relation to ventilator associated …

Background A recently published report from the United Kingdom suggested an association
between sarcoidosis and pulmonary embolism (PE). We sought to examine whether this …

Since there is some clinical evidence that the clinical course of patients with chronic
obstructive pulmonary disease (COPD) may be complicated by thrombosis in the pulmonary …

Apoptosis of fibroblasts/myofibroblasts is a critical event in the resolution of tissue repair
responses; however, mechanisms for the regulation of (myo) fibroblast apoptosis/survival …

Acute inflammatory and chronic interstitial lung diseases are characterized by excessive and
persistent fibrin deposition in the lung. Intraalveolar fibrin accumulation, observed under …

Purpose Deposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI).
Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during …

Fibrosis causes irreversible damage to lung structure and function in restrictive lung
diseases such as idiopathic pulmonary fibrosis (IPF). Extravascular coagulation involving …