Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted,
damaged, or infected cells in multicellular organisms and also in diverse biological …

Cytochrome c is primarily known for its function in the mitochondria as a key participant in
the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic …

Autophagy and apoptosis are two important catabolic processes contributing to the
maintenance of cellular and tissue homeostasis. Autophagy controls the turnover of protein …

Caspases are a family of cysteine proteases widely known as the principal mediators of the
apoptotic cell death response, but considerably less so as the contributors to the regulation …

Centrosomes, the main microtubule-organizing centers in animal cells, are replicated
exactly once during the cell division cycle to form the poles of the mitotic spindle …

Heat has been used as a medicinal and healing modality throughout human history. The
combination of hyperthermia (HT) with radiation and anticancer agents has been used …

Centrosomes are membrane-less organelles that orchestrate a wide array of biological
functions by acting as microtubule organizing centers. Here, we report that caspase-2 …

The conversion of early stage tumors into invasive malignancies with an aggressive
phenotype has been associated with the irreversible loss of E‐cadherin expression. The …

Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family
and has been implicated in both apoptotic and non-apoptotic signaling pathways, including …