Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …

The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …

An unexpectedly large fraction of genes in metazoans (human, mouse, zebrafish, worm, fruit
fly) express high levels of circularized RNAs containing canonical exons. Here we report that …

Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes
by promoting degradation or repressing translation of target mRNAs. miRNA expression is …

Vive la différence: biogenesis and evolution of microRNAs in plants and animals | Genome
Biology Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Both eukaryotes and prokaryotes (archaea and bacteria) encode an arsenal of immune
systems that protect the host against mobile genetic elements (MGEs) including viruses …

Choanoflagellates, the closest living relatives of animals, can provide unique insights into
the changes in gene content that preceded the origin of animals. However, only two …

Yeast Saccharomyces cerevisiae is an important industrial host for production of enzymes,
pharmaceutical and nutraceutical ingredients and recently also commodity chemicals and …

The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA
interference. Here we report the 3.2 Å crystal structure of Kluyveromyces polysporus …