Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous
system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity …

The amyloid hypothesis has dominated Alzheimer's disease (AD) research for almost 30
years. This hypothesis hinges on the predominant clinical role of the amyloid beta (Aβ) …

Dementia is a clinical syndrome wherein gradual decline of mental and cognitive
capabilities of an afflicted person takes place. Dementia is associated with various risk …

Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and
mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the …

Neuroinflammation is initiated with an aberrant innate immune response in the central
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …