Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Mitochondria are one of the organelles undergoing rapid alteration during the senescence
process. Senescent cells show an increase in mitochondrial size, which is attributed to the …

Lipofuscins are oxidized lipid and protein complexes that accumulate during cellular
senescence and tissue aging, regarded as markers for cellular oxidative damage, tissue …

Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates
a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated …

Skin aging is a complex process influenced by intrinsic factors and environmental stressors,
including ultraviolet (UV) radiation and air pollution, among others. In this study, we …

In space, cells sustain strong modifications of their mechanical environment.
Mechanosensitive molecules at the cell membrane regulate mechanotransduction pathways …

Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …

Population aging, a pervasive global demographic trend, is anticipated to challenge health
and social systems worldwide. This phenomenon is due to medical advancements enabling …

Replicative senescence of mesenchymal stem cells (MSCs) caused by repeated cell culture
undermines their potential as a cell therapy because of the reduction in their proliferation …

TP53-induced glycolysis and apoptosis regulator (TIGAR) regulates redox homeostasis and
provides the intermediates necessary for cell growth by reducing the glycolytic rate. During …