Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular
leak typically becomes clinically evident 3–6 days after the onset of illness, which is known …

Antibody-dependent enhancement (ADE) is a phenomenon in which preexisting poorly
neutralizing antibodies leads to enhanced infection. It is a serious concern with mosquito …

Dengue virus is the pathogenic principle behind several medical conditions. The most
common disease caused by this virus is dengue fever, characterized by high fever and flu …

Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by
eliminating pathogen-infected cells. It contains three signaling pathways: death receptor …

The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

The supply of oxygen and nutrients to the brain is vital for its function and requires a complex
vascular network that, when disturbed, results in profound neurological dysfunction. As part …

Andrographolide is a major bioactive constituent of Andrographis paniculata that has been
shown in vitro to have antiviral activity against a number of viruses, including the mosquito …

The recent Zika virus (ZIKV) outbreak in the Americas surprised all of us because of its rapid
spread and association with neurologic disorders including fetal microcephaly, brain and …