Hypoxia inducible factor (HIF) is a transcription factor that acts in low-oxygen conditions. The
cellular response to HIF activation is transcriptional upregulation of a large group of genes …

Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close
proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead …

Ferroptosis is a new form of regulated cell death. Several studies have demonstrated that
ferroptosis was involved in multiple diseases. However, the precise role of ferroptosis in …

Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy.
Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress …

Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as
rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is …

The AP-1 transcription factor c-Jun is a master regulator of the axonal response in neurons.
c-Jun also functions as a negative regulator of myelination in Schwann cells (SCs) and is …

Abstract Cancer-associated fibroblasts (CAFs), a predominant component of the tumor
microenvironment, contribute to aggressive angiogenesis progression. In clinical practice …

The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and
collagenolytic enzymes. The molecular mechanisms underlying metabolic adaptation to the …

Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has …