Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

[HTML][HTML] Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria

G Batoni, G Maisetta, S Esin - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Biofilm-associated infections represent one of the major threats of modern medicine. Biofilm-
forming bacteria are encased in a complex mixture of extracellular polymeric substances …

Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies

F Alcayaga-Miranda, J Cuenca, M Khoury - Frontiers in immunology, 2017 - frontiersin.org
While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …

Therapeutic potential of antimicrobial peptides in polymicrobial biofilm-associated infections

G Batoni, G Maisetta, S Esin - International Journal of Molecular Sciences, 2021 - mdpi.com
It is widely recognized that many chronic infections of the human body have a polymicrobial
etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis …

Antimicrobial peptides as mediators of innate immunity in teleosts

BA Katzenback - Biology, 2015 - mdpi.com
Antimicrobial peptides (AMPs) have been identified throughout the metazoa suggesting their
evolutionarily conserved nature and their presence in teleosts is no exception. AMPs are …

pH dependent antimicrobial peptides and proteins, their mechanisms of action and potential as therapeutic agents

E Malik, SR Dennison, F Harris, DA Phoenix - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have
been extensively investigated as a potential solution to the global problem of infectious …

Natural and synthetic peptides with antifungal activity

T Ciociola, L Giovati, S Conti, W Magliani… - Future medicinal …, 2016 - Taylor & Francis
In recent years, the increase of invasive fungal infections and the emergence of antifungal
resistance stressed the need for new antifungal drugs. Peptides have shown to be good …

Characterization and antibacterial activity of 7S and 11S globulins isolated from cowpea seed protein

S Abdel-Shafi, AR Al-Mohammadi, A Osman, G Enan… - Molecules, 2019 - mdpi.com
The present work was carried out to determine the characteristics and antibacterial activity of
7S and 11S globulins isolated from cowpea seed (Vigna unguiculata (L.) Walp.). The …

Innate inspiration: antifungal peptides and other immunotherapeutics from the host immune response

DK Mercer, DA O'Neil - Frontiers in Immunology, 2020 - frontiersin.org
The purpose of this review is to describe antifungal therapeutic candidates in preclinical and
clinical development derived from, or directly influenced by, the immune system, with a …

Hepcidin and its therapeutic potential in neurodegenerative disorders

ZM Qian, Y Ke - Medicinal Research Reviews, 2020 - Wiley Online Library
Abnormally high brain iron, resulting from the disrupted expression or function of proteins
involved in iron metabolism in the brain, is an initial cause of neuronal death in …