Objective To review the current knowledge on bone health in patients with hemophilia A and
the underlying pathogenetic mechanisms. Data Sources Original research articles, meta …

Hemophilia A is an X-linked hereditary disorder that results from deficient coagulation factor
VIII (FVIII) activity, leading to spontaneous bleeding episodes, particularly in joints and …

Introduction Progressive arthropathy is the main cause of morbidity in patients with severe
haemophilia. Diagnostic imaging can detect even subclinical arthropathy and impact …

Objective The aim of this research was to determine whether systemic inflammatory
indicators, including aggregate index of systemic inflammation (AISI), neutrophils …

Haemophilia is associated with reduced bone mass and mineral density. Due to the rarity of
the disease and the heterogeneity among the studies, the pathogenesis of bone loss is still …

Introduction The relationship between severe hemophilia and osteoporosis has been well
established in the literature. However, although the importance of its prevention in order to …

Objectives: The objectives of this study were to study bone mineral content (BMC), bone
mineral density (BMD), vitamin D level, and bone turnover markers in children with …

Background: Bone disease-related fractures constitute a heavy burden on the healthcare
systems and economy. Vitamin D is an important regulator of bone health and its deficiency …

Background: Bleeding episodes in severe hemophilia may occur more frequently and
spontaneously after mild trauma or daily activities. An inadequate treatment of that bleeding …

Introduction In people with haemophilia (PWH), recurrent episodes of bleeding lead to joint
deterioration and bone resorption. To date, the effects of various other factors on bone …