Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a …

KM Allan, MA Astore, E Kardia, SL Wong… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF
transmembrane conductance regulator (CFTR) gene, with some leading to non-classical …

Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia

SL Wong, E Kardia, A Vijayan, B Umashankar… - International Journal of …, 2023 - mdpi.com
Localized and chronic hypoxia of airway mucosa is a common feature of progressive
respiratory diseases, including cystic fibrosis (CF). However, the impact of prolonged …

O papel da Tirosina Quinase SmFES na esquistossomose: estudos funcionais, avaliação da atividade de compostos e da regulação transcricional em Schistosoma …

GP Torres - 2024 - arca.fiocruz.br
A quinase SmFES participa de vias de transdução de sinais em Schistosoma mansoni
envolvidas na transformação larval após a penetração nos hospedeiros. Em estudos …

Pseudomonas aeruginosa and Tobramycin Effects on Aspergillus fumigatus Infection in Cystic Fibrosis Airway

TA Nguyen - 2024 - search.proquest.com
Aspergillus fumigatus (Af) is one of the most common molds in the airways of people with
Cystic Fibrosis (pwCF). The infection of Af is often preceded by Pseudomonas aeruginosa …

Uncovering Developmental Trajectories of Airway Cells With Single-Cell RNA-Sequencing

H Welfley - 2023 - search.proquest.com
The lung is a complex organ that requires proper development, maintenance, and renewal
of specialized cell types to support every stage of life. A better understanding of the …

[PDF][PDF] Katelin M. Allan1, 2, 3, Miro A. Astore4, Egi Kardia1, 2, 3, Sharon L. Wong1, 2, 3, Laura K. Fawcett1, 2, 3, 5, Jessica L. Bell1, 6, Simone Visser7, Po-Chia Chen4 …

R Griffith, A Jaffe, S Sivam, O Vittorio, S Kuyucak… - 2023 - academia.edu
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF
transmembrane conductance regulator (CFTR) gene, with some leading to non-classical …