Traumatic peripheral nerve injury represents a major clinical and public health problem that
often leads to significant functional impairment and permanent disability. Despite modern …

Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …

Abstract Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. The
predominant subtype, CMT-1A, accounts for more than 50% of all cases and is associated …

Without medical progress, dementing diseases such as Alzheimer's disease will become
one of the main causes of disability. Preventing or delaying them has thus become a real …

We have previously shown that progesterone (PROG) is synthesized by Schwann cells and
promotes myelin formation in the peripheral nervous system (PNS). We now report that this …

Although progesterone is a steroid hormone mainly associated with female reproductive
functions, such as uterine receptivity and maintenance of pregnancy, accumulating data …

The term “neurosteroid”(NS) was introduced by Baulieu in 1981 to name a steroid hormone,
dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long …

Progesterone and its metabolites promote the viability of neurons in the brain and spinal
cord. Their neuroprotective effects have been documented in different lesion models …

Progesterone (PROG) is synthesized in the brain, spinal cord and peripheral nerves. Its
direct precursor pregnenolone is either derived from the circulation or from local de novo …

Proteins involved in the intramitochondrial trafficking of cholesterol, the first step in
steroidogenesis, such as the steroidogenic acute regulatory protein (StAR) and the …