Small molecule selenium-containing compounds: Recent development and therapeutic applications

H Chuai, SQ Zhang, H Bai, J Li, Y Wang, J Sun… - European Journal of …, 2021 - Elsevier
Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …

[HTML][HTML] Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

V Gandin, P Khalkar, J Braude… - Free Radical Biology and …, 2018 - Elsevier
Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

AM Roccaro, A Sacco, B Thompson… - Blood, The Journal …, 2009 - ashpublications.org
Detailed genomic studies have shown that cytogenetic abnormalities contribute to multiple
myeloma (MM) pathogenesis and disease progression. Nevertheless, little is known about …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail

GS Inamdar, SRV Madhunapantula… - Biochemical …, 2010 - Elsevier
The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma
development making it an important therapeutic target. In normal cells, the tightly regulated …

Drug delivery nanoparticles in skin cancers

C Dianzani, GP Zara, G Maina… - BioMed research …, 2014 - Wiley Online Library
Nanotechnology involves the engineering of functional systems at nanoscale, thus being
attractive for disciplines ranging from materials science to biomedicine. One of the most …

Development and therapeutic potential of selenazo compounds

AC Ruberte, C Sanmartin, C Aydillo… - Journal of Medicinal …, 2019 - ACS Publications
Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

Mechanisms of selenium enrichment and measurement in brassicaceous vegetables, and their application to human health

M Wiesner-Reinhold, M Schreiner… - Frontiers in Plant …, 2017 - frontiersin.org
Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds
of millions of people worldwide, particularly in developing countries, and there is increasing …

miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development

W Wei, HB He, WY Zhang, HX Zhang, JB Bai… - Cell death & …, 2013 - nature.com
MicroRNAs (miRNAs) are a type of endogenous noncoding small RNAs involved in the
regulation of multiple biological processes. Recently, miR-29 was found to participate in …

Proline-rich Akt substrate of 40 kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway

H Wang, Q Zhang, Q Wen, Y Zheng, P Lazarovici… - Cellular signalling, 2012 - Elsevier
Modifications in signaling of the proline-rich Akt substrate of 40-kDa (PRAS40) pathway is
implicated in type 2 diabetes and melanoma. PRAS40 is known for its ability to regulate the …