A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

The host cell membrane-associated RING-CH 8 protein (MARCH8), a member of the E3
ubiquitin ligase family, regulates intracellular turnover of many transmembrane proteins and …

African swine fever is one of the most devastating swine diseases caused by African swine
fever virus (ASFV). Although ASFV encodes more than 160 viral proteins, the implication of a …

The NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous
damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 …

Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported
to inhibit viral replication through multiple modes. Previous work showed that human …

Type I interferon (IFN)-mediated responses operate a pivotal role in the first line of host
immune defense against viruses. Upon DNA virus infection, DNA sensing cyclic GMP-AMP …

Abstract Interleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil
maturation, activation, chemotaxis and survival. Inhibition of IL-5 signaling is considered a …

The suppressor of cytokine signaling (SOCS) proteins family comprising eight proteins
(SOCS1-7 and cytokine-inducible SH2-containing (CIS)) are classical feedback inhibitors of …

Inflammasome activation and pyroptotic cell death are known to contribute to the
pathogenesis of cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) …

Membrane-associated RING (really interesting new gene)-cysteine-histidine (CH)(MARCH)
ubiquitin ligases belong to a RING finger domain E3 ligases family. So far, eleven members …