Shaping immunity: The influence of natural selection on population immune diversity
Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …
challenges. Such variation is widespread and affects individual and population‐level …
EpiVar Browser: advanced exploration of epigenomics data under controlled access
DR Lougheed, H Liu, KA Aracena, R Grégoire… - …, 2024 - academic.oup.com
Motivation Human epigenomic data has been generated by large consortia for thousands of
cell types to be used as a reference map of normal and disease chromatin states. Since …
cell types to be used as a reference map of normal and disease chromatin states. Since …
DNA methylation-environment interactions in the human genome
Previously, we showed that a massively parallel reporter assay, mSTARR-seq, could be
used to simultaneously test for both enhancer-like activity and DNA methylation-dependent …
used to simultaneously test for both enhancer-like activity and DNA methylation-dependent …
[HTML][HTML] Improved multi-ancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
Multi-ancestry statistical fine-mapping of cis-molecular quantitative trait loci (cis-molQTL)
aims to improve the precision of distinguishing causal cis-molQTLs from tagging variants …
aims to improve the precision of distinguishing causal cis-molQTLs from tagging variants …