Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Paradoxically, trichothecenes have both immunosuppressive and immunostimulatory
effects. The underlying mechanisms have not been fully explored. Early studies show that …

The antimetabolite 5-fluorouracil is a widely used chemotherapeutic for the treatment of
several solid cancers. However, resistance to 5-fluorouracil remains a major drawback in its …

Stress granules (SGs) can assemble in cancer cells upon chemotoxic stress. Glucocorticoids
function during stress responses and are administered with chemotherapies. The roles of …

Glioblastomas, accounting for approximately 50% of gliomas, comprise the most aggressive,
highly heterogeneous, and malignant brain tumors. The objective of this study was to …

Triple-negative breast cancers (TNBCs) are heterogeneous and metastatic, and targeted
therapy is highly needed for TNBC treatment. Recent studies showed that extracellular …

The traditional perception of ribosomes as uniform molecular machines has been
revolutionized by recent discoveries, revealing a complex landscape of ribosomal …

Neuroendocrine (NE) cancers arise from cells within the neuroendocrine system.
Chemotherapies and endoradiotherapy have been developed, but their clinical efficacy is …

Stress granules are cytoplasmic structures that form in response to a variety of cellular
stresses. They contain mRNAs and many proteins including numerous types of RNA …

Clear cell renal cell carcinoma (CC-RCC) is the most lethal of all genitourinary cancers. The
functional loss of the von Hippel-Lindau (VHL) gene occurs in 90% of CC-RCC, driving …