Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction

P Severino, A D'Amato, M Pucci, F Infusino… - International journal of …, 2020 - mdpi.com
Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …

Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy

J Yang, Z Liu - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Microvascular dysfunction in diabetes mellitus and cardiometabolic disease

WB Horton, EJ Barrett - Endocrine reviews, 2021 - academic.oup.com
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance

D Sun, J Wang, S Toan, D Muid, R Li, X Chang, H Zhou - Angiogenesis, 2022 - Springer
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Molecular complexities underlying the vascular complications of diabetes mellitus–A comprehensive review

S Paul, A Ali, R Katare - Journal of Diabetes and its Complications, 2020 - Elsevier
Diabetes is a chronic disease, characterized by hyperglycemia, which refers to the elevated
levels of glucose in the blood, due to the inability of the body to produce or use insulin …

Inflammation in metabolic cardiomyopathy

FA Wenzl, S Ambrosini, SA Mohammed… - Frontiers in …, 2021 - frontiersin.org
Overlapping pandemics of lifestyle-related diseases pose a substantial threat to
cardiovascular health. Apart from coronary artery disease, metabolic disturbances linked to …

Extra virgin olive oil and cardiovascular diseases: Benefits for human health

C Nocella, V Cammisotto, L Fianchini… - … Metabolic & Immune …, 2018 - ingentaconnect.com
Background and Objective: The cardioprotective properties of Mediterranean Diet were
demonstrated for the first time from the Seven Country Study. In the last few decades …

Foot ulceration and its association with mortality in diabetes mellitus: a meta‐analysis

S Saluja, SG Anderson, I Hambleton, H Shoo… - Diabetic …, 2020 - Wiley Online Library
Background Diabetic foot ulcers portend an almost twofold increase in all‐cause mortality
compared with diabetes on its own. Aim To investigate the association between diabetic foot …

Isorhapontigenin attenuates cardiac microvascular injury in diabetes via the inhibition of mitochondria-associated ferroptosis through PRDX2-MFN2-ACSL4 pathways

Y Chen, S Li, M Yin, Y Li, C Chen, J Zhang, K Sun… - Diabetes, 2023 - Am Diabetes Assoc
Ferroptosis is a newly identified form of regulated cell death that is driven by iron overload
and uncontrolled lipid peroxidation, but the role of ferroptosis in cardiac microvascular …