An adenine base editor variant expands context compatibility
Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …
Dimerization of the deaminase domain and locking interactions with Cas9 boost base editing efficiency in ABE8e
CRISPR-based DNA adenine base editors (ABEs) hold remarkable promises to address
human genetic diseases caused by point mutations. ABEs were developed by combining …
human genetic diseases caused by point mutations. ABEs were developed by combining …
MutaT7GDE: A Single Chimera for the Targeted, Balanced, Efficient, and Processive Installation of All Possible Transition Mutations In Vivo
AA Mengiste, JL McDonald, MT Nguyen Tran… - ACS Synthetic …, 2024 - ACS Publications
Deaminase− T7 RNA polymerase fusion (MutaT7) proteins are a growing class of synthetic
biology tools used to diversify target genes during in vivo laboratory evolution. To date …
biology tools used to diversify target genes during in vivo laboratory evolution. To date …
[HTML][HTML] Unlocking the secrets of ABEs: the molecular mechanism behind their specificity
X Chen, MJ McAndrew… - Biochemical Society …, 2023 - portlandpress.com
CRISPR–Cas, the bacterial immune systems, have transformed the field of genome editing
by providing efficient, easily programmable, and accessible tools for targeted genome …
by providing efficient, easily programmable, and accessible tools for targeted genome …