The relationship between migraines and allergies is controversial. Though they are
epidemiologically linked, the underlying pathophysiological connection between them …

In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, positron emission tomography (PET), and single-photon …

In search of new dual-acting histamine H3/sigma-1 receptor ligands, we designed a series
of compounds structurally based on highly active in vivo ligands previously studied and …

In the framework of the multitarget inhibitor study, we report an in silico analysis of 1, 2-
dibenzoylhydrazine (DBH) with respect to three essential receptors such as the ecdysone …

The development of diazabicyclo [4.3. 0] nonane and 2, 7-diazaspiro [3.5] nonane
derivatives as sigma receptors (SRs) ligands is reported. The compounds were evaluated in …

Designing and discovering compounds for dual-target inhibitors is challenging to synthesize
new, safer, and more efficient drugs than single-target drugs, especially to treat multifactorial …

For decades now, computational chemistry has allowed us to shorten experimental times to
meet the needs of humanity in finding solutions. In this regard, we tried to exploit tools such …

Background Although the terms “agonist” and “antagonist” have been used to classify sigma-
1 receptor (σ1R) ligands, an unambiguous definition of the functional activity is often hard. In …

Piperidine is an essential moiety of morphine, responsible for the analgesic activity. Among
number of other analgesic targets, µ-opioid receptor is still the most focused and …

Despite the recent advancements in ionic liquids, incorporating these liquids into solid
networks, particularly ionogels, to achieve new properties such as improved thermal and …