Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Over the previous two decades, a diverse array of geochemical negative emissions
technologies (NETs) have been proposed, which use alkaline minerals for removing and …

Continuous evolution can generate biomolecules for synthetic biology and enable
evolutionary investigation. The orthogonal DNA replication system (OrthoRep) in yeast can …

Microbial communities are shaped by viral predators. Yet, resolving which viruses (phages)
and bacteria are interacting is a major challenge in the context of natural levels of microbial …

Bacteriophages are the most abundant biological entity in the world and hold a tremendous
amount of unexplored genetic information. Since their discovery, phages have drawn a great …

Metabolic engineering holds the promise to transform the chemical industry and to support
the transition into a circular bioeconomy, by engineering cellular biocatalysts that efficiently …

Creating and characterizing individual genetic variants remains limited in scale, compared
to the tremendous variation both existing in nature and envisioned by genome engineers …

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated
transposases have the potential to transform the technology landscape for kilobase-scale …

Bacteriophage genome editing can enhance the efficacy of phages to eliminate pathogenic
bacteria in patients and in the environment. However, current methods for editing phage …

The development of bacterial chassis to increase productivity and reduce industrial costs in
value-added biochemical production has gained significant attention. Current efforts have …